The problem of different key strokes on different programs can be configured away mostly. Gimp is highly adaptable.

I think this might not be as useful as it looks. With a normal keyboard, you know where the keys are, and the only thing you have to memorize is which shortcut corresponds to what action of the program you are using. With a keyboard like this you also have to learn the new positions of all the keys. It’s gonna take you a lot of practise to get used to it. Perhaps just as much as it would take to memorize the key combinations of your standard keyboard. And in the beginning of learning, while you’re not yet fluent with your special keyboard, you always have to look for your keys, which will perhaps take you longer than clicking on the icons or menus with your mouse, while on a standard keyboard, at least the (few) combinations you already know can be used very quickly because you already know where the keys are.

Still, this thing looks cool. Once you’re used to it, you may be able to work very fast with it. Although then you won’t be needing the special labels on the keys any more…